TABLE 3.
Genotype effects on neocortical 5‐HT2AR binding
| Genotype/comparison | Estimate a | 95% CI |
|---|---|---|
| rs6313 | ||
| TT | 1.21 | 1.06, 1.38 |
| TC | 1.22 | 1.09, 1.36 |
| CC | 1.19 | 1.09, 1.31 |
| TT vs. TC | −0.01 (1.06%) | −0.17, 0.16 |
| TT vs. CC | 0.02 (1.42%) | −0.14, 0.18 |
| TC vs. CC | 0.03 (2.45%) | −0.09, 0.15 |
| rs6314 | ||
| Y‐carriers | 1.09 | 0.93, 1.25 |
| HH | 1.21 | 1.11, 1.32 |
| Y‐carriers vs. HH | −0.11 (10.24%) | −0.24, 0.01 |
| rs7997012 | ||
| GG | 1.23 | 1.10, 1.36 |
| AG | 1.25 | 1.13, 1.39 |
| AA | 1.14 | 1.02, 1.27 |
| GG vs. AG | −0.02 (1.97%) | −0.15, 0.10 |
| GG vs. AA | 0.09 (7.10%) | −0.06, 0.24 |
| AG vs. AA | 0.11 (8.90%) | −0.04, 0.28 |
| 5‐HTTLPR b | ||
| S′S′ | 1.24 | 1.09, 1.40 |
| LAS′ | 1.20 | 1.10, 1.31 |
| LALA | 1.15 | 1.01, 1.28 |
| S′S′ vs. LAS′ | 0.04 (3.34%) | −0.09, 0.18 |
| S′S′ vs. LALA | 0.09 (7.43%) | −0.07, 0.27 |
| LAS′ vs. LALA | 0.05 (4.23%) | −0.06, 0.17 |
Note: 5‐HT2AR: serotonin 2A receptor. 95% CI: 95% confidence intervals.
a
Genotype differences (%) noted where relevant.
b
5‐HTTLPR comprises rs4795541 and rs25531 with S′ denoting either composite LG allele or S allele, in accordance with Hu et al. (2006).