Table 3.

Echocardiographic characteristics

	Overall population (n=118)	AL (1)(n=26)	Wild-type ATTR (2)(n=80)	Variant-type ATTR (3)(n=12)	P value	1 versus 2	Posthoc analysis 2 versus 3	3 versus 1
Interventricular wall thickness—mm	17±3	15±2	18±3	17±4	0.007	0.002	0.310	0.170
LVEF—%	51±13	52±13	50±13	56±11	0.242
LV stroke volume—mL	50±19	50±20	50±19	52±18	0.825
MCF—%	19±9	22±12	17±9	21±9	0.094
Left atrial volume index—mL/m2	43±15	38±13	45±14	43±23	0.078
E wave—cm/s	82±23	87±27	80±21	84±25	0.478
A wave—cm/s	59±31	71±38	53±26	63±29	0.129
E/A	1.5 (0.8–2.7)	1.3 (0.7–2)	1,8 (0.9–2.8)	1 (0.9–1.6)	0.324
e’ wave—cm/s	6±2	6±2	6±2	7±2	0.283
E/e’	15±7	16±7	15±7	16±12	0.728
Deceleration time—ms	206±84	188±63	212±93	208±52	0.449
GLS—%	11±4	11±2	10±4	15±5	0.006	0.214	0.003	0.010
Relative apical LS	1.1 (0.9–1.4)	1 (0.9–1.2)	1.2 (0.9–1.5)	0.9 (0.9–1)	0.043	0.048	0.068	0.456
GWI—mm Hg%	1169±538	1094±422	1091±502	1755±730	0.012	0.840	0.004	0.010
GWE—%	87±8	89±8	86±8	91±5	0.049	0.053	0.066	0.741
Global constructive work—mm Hg%	1344±562	1225±406	1290±506	1965±822	0.013	0.654	0.005	0.008
Global wasted work—mm Hg%	120±100	101±95	128±106	107±68	0.241	0.090	0.772	0.442

Data are presented as number (percent), mean±SD if normally distributed or median (IQR) if not normally distributed.

AL, light chain amyloidosis; ATTR, transthyretin amyloidosis; GLS, global longitudinal strain; GWE, global work efficiency; GWI, global work index; LV, left ventricular; LVEF, LV ejection fraction; MCF, myocardial contraction fraction.