Table 2.
Compound | R1 | R2 | R3 | R4 | R5 | R2′ | R3′ | R4′ | R5′ | X | Yield (%) |
---|---|---|---|---|---|---|---|---|---|---|---|
19 | H | OMe | H | OMe | H | OMe | H | H | OMe | CH2 | 81 |
20 | H | OMe | H | H | OMe | OMe | H | OMe | H | CH2 | 77 |
21 | H | H | H | OMe | H | OMe | H | H | OMe | CH2 | 50 |
22 | H | OMe | H | H | OMe | OMe | H | H | OMe | CH2 | 65 |
23 | H | OMe | H | OMe | H | OMe | H | OMe | H | CH2 | 74 |
24 | H | H | OMe | OMe | H | OMe | H | H | OMe | CH2 | 73 |
25 | H | H | H | OMe | H | H | OMe | OMe | H | CH2 | 81 |
26 | H | H | H | OMe | H | OMe | H | OMe | H | CH2 | 76 |
27 | (4-OMe)Ph | H | H | OMe | H | OMe | H | H | OMe | CH2 | 28 |
28 | (2,5-OMe)Bn | H | H | OMe | H | OMe | H | H | OMe | CH2 | 74 |
29 | H | OMe | H | OMe | H | OMe | H | H | OMe | NH | 55 |
30 | H | OMe | H | H | OMe | H | H | OMe | H | NH | 85 |
31 | H | OMe | H | H | OMe | H | OMe | OMe | H | NH | 69 |
32 | H | H | OMe | OMe | H | H | H | OMe | H | NH | 42 |
33 | H | H | H | OMe | H | H | H | OMe | H | NH | 80 |
34 | H | OMe | H | H | OMe | OMe | H | H | OMe | NH | 84 |
35 | (4-OMe)Ph | H | H | OMe | H | H | H | OMe | H | NH | 63 |
36 | (2,5-OMe)Bn | H | H | OMe | H | OMe | H | H | OMe | NH | 17 |