OSCC	Oral squamous cell carcinoma
IGF1R	Insulin-like growth factor 1 receptor
PI3KCA	Phosphatidylinositol 3-kinase
AKT-PKB	Protein kinase B
RAS/RAF/MAPK	Mitogen-activated protein kinases pathway
TCGA	The Cancer Genome Atlas
PRKCI	Protein kinase C iota
GLI	Glioma-associated oncogene
IGF-1	Insulin-like growth factor 1
HH	Hedgehog
IL	Interleukin
CAF	Cancer-associated fibroblasts
TGF-β	Transforming growth factor beta
MMP	Matrix metallopeptidases
HGF	Hepatocyte growth factor
EGF	Epidermal growth factor
CTGF	Connective tissue growth factor
SMO	Smoothened
SHH	Sonic hedgehog
PTCH1	Patched 1
IHH	Indian hedgehog
IGFBP	Insulin-like growth factor-binding protein
MF1	Human dermal fibroblasts
MF1-IGF1	Human dermal fibroblasts-expressing IGF-1
TNF-TRAIL	Tumor necrosis factor-related apoptosis-inducing ligand
CRISPR/Cas9	clustered regularly interspaced short palindromic repeats/CRISPR associated protein 9
CD	Cluster differentiation
MOI	Multiplicity of infection
sgRNA	single guide RNA
DMEM	Dulbecco’s modified Eagle’s medium
CM	Conditioned medium