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Mitochondrial functions of Cdc48/p97. Cdc48/p97 mediates mitochondrial-associated degradation (MAD), by extraction and unfolding of mitochondrial substrates and promotes mitochondrial fusion by segregating and disassembling the fusion complex. By assisting the degradation of both pro- and antiapoptotic factors, Cdc48/p97 regulates apoptosis and by controlling the ubiquitylation levels at mitochondria it enables PINK1/Parkin dependent mitophagy.
