Table 2.
Overview of the rating results in terms of the prognostic significance.
| Mean Bud Count | Bd1 1 | Bd2 1 | Bd3 1 | p | |||||
|---|---|---|---|---|---|---|---|---|---|
| H & E 1 | CK | ||||||||
| 0.785 mm2 | 0.785 mm2 | n | % | n | % | n | % | ||
| Rcons (sCK) | 164 | 43 | 22 | ||||||
| Death | 60 | 37% | 21 | 49% | 12 | 55% | 0.22 | ||
| Cancer-specific death | 17 | 10% | 5 | 12% | 5 | 23% | 0.26 | ||
| Distant metastasis | 27 | 16% | 10 | 23% | 7 | 32% | 0.15 | ||
| Investigator 1 | 4.9 ± 5.8 | 11.2 ± 13.5 | 144 | 29 | 56 | ||||
| Death | 56 | 39% | 13 | 45% | 24 | 43% | 0.72 | ||
| Cancer-specific death | 12 | 8% | 5 | 17% | 10 | 18% | 0.22 | ||
| Distant metastasis | 21 | 15% | 6 | 21% | 17 | 30% | 0.15/0.05 * | ||
| Investigator 2 | 2.9 ± 3.1 | 7.0 ± 5.7 | 154 | 52 | 23 | ||||
| Death | 64 | 42% | 17 | 33% | 12 | 52% | 0.20 | ||
| Cancer-specific death | 17 | 11% | 4 | 8% | 6 | 26% | 0.02 | ||
| Distant metastasis | 31 | 20% | 6 | 12% | 7 | 30% | 0.13/0.04 ° | ||
| Investigator 3 | 2.8 ± 3.4 | 6.6 ± 6.7 | 176 | 48 | 5 | ||||
| Death | 62 | 35% | 29 | 60% | 2 | 40% | 0.01 | ||
| Cancer-specific death | 19 | 11% | 7 | 15% | 1 | 20% | 0.48 | ||
| Distant metastasis | 28 | 16% | 16 | 33% | 0 | 0% | 0.01 | ||
| Investigator 5 | 4.1 ± 4.4 | 11.1 ± 7.5 | 138 | 59 | 32 | ||||
| Death | 50 | 36% | 28 | 47% | 15 | 47% | 0.51 | ||
| Cancer-specific death | 10 | 7% | 10 | 17% | 7 | 22% | 0.05 | ||
| Distant metastasis | 21 | 15% | 11 | 19% | 12 | 38% | 0.01 | ||
| Investigator 6 | 2.7 ± 2.9 | 7.7 ± 5.8 | 167 | 48 | 14 | ||||
| Death | 68 | 41% | 19 | 40% | 6 | 43% | 0.94 | ||
| Cancer-specific death | 18 | 11% | 8 | 17% | 1 | 7% | 0.43 | ||
| Distant metastasis | 32 | 19% | 10 | 21% | 2 | 14% | 0.71 | ||
| Investigator 7 | 4.2 ± 9.5 | 10.1 ± 13.9 | 162 | 30 | 37 | ||||
| Death | 61 | 38% | 15 | 50% | 17 | 46% | 0.30 | ||
| Cancer-specific death | 16 | 10% | 6 | 20% | 5 | 14% | 0.18 | ||
| Distant metastasis | 28 | 17% | 9 | 30% | 7 | 19% | 0.19 | ||
1 the bud counting for bd grading was performed on H & E; a cytokeratin staining was available as support for the identification of buds; p: values for Kaplan–Meier analyses; pairwise comparisons: * Bd1 vs. Bd3 p = 0.049; ° Bd2 vs. Bd3 p = 0.042. The bold numbers are statistically significant.