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. 2020 Sep 11;21(18):6663. doi: 10.3390/ijms21186663

Figure 1.

Figure 1

MuRF1 structure and known regions of interaction with some partners. MuRF1 structure is characterized by a RBCC (RING-B-box-coiled-coil) motif constituted by an N-terminal RING domain (23–79), a MuRF family specific motif (MFC) motif (79–113), a B-box type 2 (Bb2) domain (117–161), a central helical domain (166–328) with a COS-box motif (269–328) and a C-terminal acidic tail (328–353). Several regions have been identified for their interaction with MuRF1 partners (substrates in dark blue and other interactors in light blue): Titin [2], cardiac troponin I [21,28], muscle-type creatine kinase (MCK) [29], c-Jun [22], the ubiquitin conjugating enzymes (UBE2s) [30], CARP 119–325 [31]. HD, helical domain.