Table 2.
Regulation of lncRNAs in brain and blood samples of PD patients.
| lncRNA | Regulation | No. of Samples | Sample Type | Reference |
|---|---|---|---|---|
| lincRNA-p21 MALAT1 SNHG1 NEAT1 * H19 |
↑ ↑ ↑ ↑ ↓ |
20 PD vs. 10 controls | Human brain specimens | [115] |
|
AL049437 AK021630 |
↑ ↓ |
11 PD vs. 14 controls | Tissue samples | [118] |
| U1 RP11-462G22.1 |
↓ ↓ |
3 PD vs. 3 controls | Blood Leukocytes | [119] |
|
AC131056.3-001 HOTAIRM1 lnc-MOK-6:1 RF01976.1-201 |
↑ ↑ ↑ ↑ |
72 PD vs. 22 controls | Blood Leukocytes | [120] |
| NEAT1 * | ↑ | 61 PD vs. 42 controls | PBMC | [117] |
| AS-Uchl1 | ↓ | 68 PD vs. 65 controls | Plasma | [121] |
PBMC: peripheral blood mononuclear cells; PD: Parkinson’s disease; vs.: versus; * lncRNAs found to be differentially expressed in more than one cohort; ↑ or ↓ symbolize up or down regulation of lncRNA expression.