Table 2.

Circulating miRNAs differentially expressed in elderly compared to healthy young after exercise.

Subjects	Type of Exercise	Duration a	c-miRNAs b		Reference
Male marathon runners (51.6–62 yr old)	Endurance acute exercise bout	30 min/4 hrs	Immediately post-exercise: ↑miR-126, miR-133		[157]
Male marathon runners (50.4–53.2 yr old)	Endurance acute exercise bout	Immediately post/up to 24 hrs	Immediately post exercise: ↑miR-1, miR-126, miR-133a, miR-134, miR-146a, miR-208a, miR-499-5p		[158]
Healthy, inactive, young (21–23 yr) and old (72–76 yr)	Resistance acute exercise bout	6 hrs	Young ↑miR-19b-3p, miR-195-5p, miR-19a-3p, miR-106-5p, miR-20a-5p, miR-17-5p, miR-143-3p, miR-26b-5p, miR-93-5p		[155]
Low (40.6–52 yr) and high (42–54.4 yr) responding men and women to a weight loss intervention	Resistance exercise training and diet intervention	16 wks	Both groups: ↑221-3p, 223-3p Only Low responder: ↑miR-140		[159]
Older trained and older sedentary men (>65 yr old)	Endurance acute exercise bout	40 min	Trained group		[160]
			Immediately post exercise ↑miR-383-5p, miR-339-5p, miR-874-3p ↓miR-206, miR-486-5p, miR-148a-3p, let-7b-5p	3 hrs post exercise↑miR-34b-3p, miR-129-2-3p, miR-138-1-3p, miR-671-3p, miR-885-5p ↓miR-486-5p, miR-629-5p, miR-16-2-3p
			Sedentary group
			Immediately post exercise ↑ miR-505-3p, miR-29b-3p, miR-203a-3p, miR-384, miR-451a, miR-223-3p, miR-218-5p, miR-495-3p	3 hrs post exercise ↓miR-4433b-3p, miR-378c, miR-151b, miR-151a-5p, hsa- miR-151b

^a hrs, hours; mos, months; min, minutes; yr, year; wks, weeks. ^b c-miRNAs, irculating miRNA.