Table 1.
Adaptation, protection and cell survival by preconditioning with H2O2 or polyphenols in cell-culture; in vitro systems.
| Preconditioning with | Stress Compound | Model | Molecular Target | References |
|---|---|---|---|---|
| Plant/Compound | ||||
| H2O2 (10 µM) | H2O2 (6 mM) | COS cells | ↑PI3K/Akt | [54] |
| H2O2 (100 µM, 10 min) | H2O2 (100 µM, 30 min) | Cardiomyocyte | ↑PI3K/Akt/Nrf2 | [55] |
| H2O2 (100 µM, 1.5 h) | H2O2 (100 µM, 30 h) | PC12 cells | ↑PI3K/Akt/HO-1 | [56] |
| Resveratrol (20 µM) | H2O2 (50 µM) | H9c2 cells | ↑SirT1/SirT7, ↓caspase3 | [59] |
| Resveratrol (100 µM) | H2O2 (1 mM) | C6 astrocytes | ↑GSH/SOD/HO1, ↓ROS/iNOS | [60] |
| Resveratrol (100 µM) | Ethanol (0.78%) | Keratinocytes | ↑GSH, ↓ROS | [57] |
| Baicalein (10 µM) | H2O2 (1 mM) | SH-SYSY cells | ↑Nrf2/NQO1/SirT1,↓ necrosis | [58] |
| Hesperedin (1–50 µM) | H2O2 (0.4 mM) | PC12 cells | ↑GSH-Px/cat,↓ LDH | [61] |
| Hydroxytyrosol (50 µM) | H2O2 (250 µM) | Endothelial cells | ↑cat/AMPK/FOXO3,↓ ROS | [62] |
| Quercetin (25 µM) | H2O2 (60 µM) | Neurons cells | ↑GSH/Nrf2/survival | [63] |
| Berry anthocy. (1 mg/mL) | H2O2 (500 µM) | ARPE-19 | ↑GSH-transferase/HO-1 | [64] |
| Berry juice (10 µM gallate.eq) | H2O2 (750 µM) | N2a cells | ↑GSH/SOD/MAPK/p-38 | [65] |
↑ = increase, ↓ = decrease. Gallic acid equivalent = gallate eq., Anthocyanins = anthocy.