Table 1.
Clinical-pathological features of the studied population: Asterisks (*) indicate significant prognostic variables of loco-regional secondary neoplastic manifestation at the 5%-level. p-values were obtained with the log-rank test.
| Clinical-Pathological Variables | ||||
|---|---|---|---|---|
| Patients | Relapses Observed | p-Value | ||
| Sex | Male | 17 (47%) | 6 (35%) | 0.82 |
| Female | 19 (53%) | 6 (31%) | ||
| Age | <65 | 15 (42%) | 8 (53%) | 0.35 |
| >65 | 21 (58%) | 4 (19%) | ||
| Smoke | Yes | 7 (19%) | 3 (43%) | 0.26 |
| No | 29 (81%) | 9 (31%) | ||
| Site | Tongue and floor of mouth | 13 (36%) | 4 (31%) | 0.96 |
| Buccal and labial mucosa | 7 (19%) | 3 (43%) | ||
| Gingiva, Hard Palate, Retromolar region | 16 (45%) | 5 (31%) | ||
| T stage | T1-T2 | 27 (75%) | 8 (29%) | 0.33 |
| T3-T4 | 9 (25%) | 4 (44%) | ||
| N stage | N− | 32 (89%) | 9 (28%) | 0.06 |
| N+ | 4 (11%) | 3 (75%) | ||
| Grading | G1 | 20 (56%) | 5 (25%) | 0.18 |
| G2 | 14 (39%) | 6 (43%) | ||
| G3 | 2 (5%) | 1(50%) | ||
| Surgical margins | Free | 29 (81%) | 9 (31%) | 0.83 |
| Close | 4 (11%) | 1 (25%) | ||
| Displasia | 3 (8%) | 2 (66%) | ||
| Involved | 0 (0%) | |||
| Presence of associated OPMD | None | 26 (72%) | 11 (42%) | 0.07 |
| Lichen | 6 (17%) | 0 (0%) | ||
| Leucoplakia | 4 (11%) | 1 (25%) | ||
| Depth of invasion (DOI) | <4 mm | 21 (58%) | 5 (24%) | 0.07 |
| >4 mm | 15 (42%) | 7 (47%) | ||
| Pattern of invasion | P1-P2 | 22 (61%) | 4 (18%) | 0.01 * |
| P3-P4 | 14 (39%) | 8 (57%) | ||
| Radiotherapy | Yes | 8 (22%) | 4 (50%) | 0.2 |
| No | 28 (78%) | 8 (29%) | ||