Table 2.
Cox proportional hazards model resulting from likelihood-based component-wise boosting after seven steps. The five non-zero regression coefficients (ln HR) are presented along with hazard ratios (HRs) and permutation-based p-values. Coefficients are scaled to be at the level of the original methylation Beta-values.
| CpG Site | Ln HR | HR | p-Value |
|---|---|---|---|
| EPHX3-24 (Chr19:15232040) | −0.0234 | 0.9769 | 0.0157 |
| EPHX3-26 (Chr19:15232034) | −0.0226 | 0.9777 | 0.0172 |
| ITGA4-3 (Chr2:181458175) | 0.0163 | 1.0165 | 0.0078 |
| ITGA4-4 (Chr2:181458181) | 0.0306 | 1.0310 | 0.0027 |
| MiR193-3 (Chr17:31559856) | 0.0089 | 1.0090 | 0.0099 |
| Integrated Brier score | 0.080 | ||
| C-index | 0.802 | ||
| Integrated AUC | 0.850 | ||