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. 2020 Aug 24;10(9):162. doi: 10.3390/life10090162

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Post-microgravity in vitro anti-cancer drug treatment alters rate of cancer cell migration due to F-actin reorganization. (a). Both 5 μM doxorubicin (Dox) and 1 μM daunorubicin (Dauno) enhance post-microgravity migration of cells. The reduced migration in CytoD-treated cells reveals the dependence of the migration on F-actin organization. (b). Bar chart comparing the average migration rates of post-microgravity Dox- and Dauno-treated HL-60 cells with those untreated. The anti-cancer drug-treated cells migrate significantly more (p < 0.05 for Dox and p < 0.01 for Dauno) than the untreated cells.