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. 2020 Sep 11;8(9):344. doi: 10.3390/biomedicines8090344

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Dynamic changes in TF content of lipid mediators in DES. The animals were exposed to general anesthesia for 6 h (shown as gray box). TF samples were collected before (norm) and immediately after (6 h) the general anesthesia as well as on 1, 3, and 7 day post-exposure. The concentrations of the lipid mediators (phospholipid derivatives, PUFAs and oxylipins) in TF were measured using quantitative UPLC-MS/MS analysis. * p < 0.05 as compared to the parameters of TF of the intact (control) animals. The identified oxylipins are divided into subgroups according to their precursors (AA, ALA, LA, phospholipids) and major biosynthetic pathways, involving COX, LOX, or CYP.