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. 2020 Sep 11;8(9):344. doi: 10.3390/biomedicines8090344

Figure 7.

Figure 7

Dynamic changes in TF content of lipid mediators in DES in the course of anti-inflammatory therapy. The animals were exposed to general anesthesia for 6 h (shown as gray box) and subsequently received instillations of the eye drops containing 50% DMSO (gray) or 50% DMSO with 0.5% zileuton (red), one drop three times daily in each eye for 7 days. TF samples were collected before (norm) and immediately after (6 h) the general anesthesia as well as on 1, 3, and 7 day post-exposure. The concentrations of the lipid mediators (phospholipid derivatives, PUFAs and oxylipins) in TF were measured using quantitative UPLC-MS/MS analysis. # p < 0.05 as compared to parameters of TF of the untreated animals with DES (black). * p < 0.05 as compared to parameters of TF of the animals from the DMSO or zileuton group.