Table 2.
Univariate analysis for overall survival.
| Variables | ALL (N = 160) | HSPC (N = 52) | CRPC(N = 108) | |||
|---|---|---|---|---|---|---|
| HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | |
| Gleason sum score | 0.248 | 0.454 | 0.284 | |||
| 6–7 | 1 | 1 | 1 | |||
| 8–10 | 1.30 (0.83–2.02) | 1.50 (0.52–4.29) | 1.31 (0.80–2.13) | |||
| Age | 0.559 | 0.585 | 0.843 | |||
| ≤ 68 | 1 | 1 | 1 | |||
| >68 | 1.14 (0.74–1.74) | 1.32 (0.49–3.57) | 1.05 (0.65–1.68) | |||
| WHO performance status | 0.003 | 0.196 | 0.037 | |||
| 0 | 1 | 1 | 1 | |||
| 1, 2 | 1.88 (1.24–2.86) | 1.90 (0.72–4.99) | 1.65 (1.03–2.63) | |||
| Cytoreductive extent | <0.001 | 0.007 | 0.005 | |||
| Minor cytoreduction | 1 | Ref | 1 | Ref | 1 | Ref |
| Major cytoreduction | 0.46 (0.29–0.75) | 0.002 | 0.18 (0.04–0.70) | 0.014 | 0.55 (0.33–0.93) | 0.025 |
| Total cytoreduction | 0.25 (0.14–0.46) | <0.001 | 0.18 (0.06–0.65) | 0.009 | 0.29 (0.13–0.63) | 0.002 |
| Number of osseous metastases | 0.002 | 0.127 | 0.063 | |||
| <5 | 1 | 1 | 1 | |||
| ≥5 | 2.13 (1.33–3.42) | 2.21 (0.80–6.11) | 1.72 (0.97–3.04) | |||
| Metastatic burden (CHAARTED) | <0.001 | 0.034 | 0.005 | |||
| Low | 1 | 1 | 1 | |||
| High | 2.53 (1.62–3.96) | 3.01 (1.09–8.35) | 2.10 (1.25–3.53) | |||
| Risk classification (LATITUDE) | 0.020 | 0.062 | 0.335 | |||
| Low-risk | 1 | 1 | 1 | |||
| High-risk | 1.64 (1.08–2.49) | 2.73 (0.95–7.83) | 1.26 (0.79–1.99) | |||
| Hormone sensitivity | 0.006 | |||||
| CRPC | 1 | |||||
| HSPC | 0.47 (0.28–0.80) | |||||
| PSA at radiotherapy initiation | <0.001 | 0.043 | 0.059 | |||
| >16.5 ng/ml* | 1 | 1 | 1 | |||
| ≤ 16.5 ng/ml | 0.48 (0.32–0.72) | 0.27 (0.07–0.96) | 0.63 (0.39–1.02) | |||
| PSA response | <0.001 | 0.052 | 0.002 | |||
| Decline ≤ 50% | 1 | 1 | 1 | |||
| Decline > 50% | 0.42 (0.27–0.64) | 0.36 (0.13–1.01) | 0.48 (0.30–0.77) | |||
HSPC, hormone sensitive prostate cancer; CRPC, Castration-resistant prostate cancer; PSA, Prostate-specific antigen.
*
The optimal cutoff value of PSA at radiotherapy initiation defined by ROC curves. Bold values represent the p-values that are statistically significance.