Table 3.
Human hydrolases acting on glycosphingolipids and ceramide.
| Enzyme Names | Uniprot No. | CAZy GH/clan | Activator |
|---|---|---|---|
| Glucoceramidase, GCase, GBA1 | P04062 | GH30 / GH-A | SapC |
| β-Galactoceramidase, GALC, Gal-Cer β-galactosidase | P54803 | GH59 / GH-A | SapA |
| Arylsulfatase A, ARSA | P15289 | - | SapB |
| α-Galactosidase A, GLA | P06280 | GH27 / GH-D | SapB |
| β-Galactosidase, GLB1, BGAL | P16278 | GH35 / GH-A | SapB |
| β-Hexosaminidase HEXA | P06865 | GH20 / GH-K | GM2-AP |
| β-Hexosaminidase HEXB | P07686 | GH20 / GH-K | GM2-AP |
| α-N-Acetylgalactosaminidase NAGA | P17050 | GH27 / GH-D | - |
| Sialidase NEU1 | Q99519 | GH33 / GH-E | - |
| Sialidase NEU2 | Q9Y3R4 | GH33 / GH-E | - |
| Sialidase NEU3 | Q9UQ49 | GH33 / GH-E | - |
| Sialidase NEU4 | Q8WWR8 | GH33 / GH-E | - |
| Acid ceramidase, ASAH1 | Q13510 | - | SapD |