Table 3.

Dry Eye Symptom Score (0–5, 6–10): Shift Table Between Subsequent Time Points on Day 1

N=134
Baseline Score	n	0 Hours	n/M (%)		Post-Baseline Scores
					4 Hours		n/M (%)	8 Hours	n/M (%)
(A) Overall population
0‒5	72	0‒5	69/72 (95.8)		0‒5		66/69 (95.7)	0‒5	65/66 (98.5)
								6‒10	1/66 (1.5)
					6‒10		3/69 (4.3)	0‒5	1/3 (33.3)
								6‒10	2/66 (66.7)
		6‒10	3/72 (4.2)		0‒5		3/3 (100.0)	0‒5	3/3 (100.0)
6‒10	61	0‒5	41/41 (67.2)		0‒5		32/41 (78.0)	0‒5	27/32 (84.4)
								6‒10	5/32 (15.6)
					6‒10		9/41 (22.0)	0‒5	2/9 (22.2)
								6‒10	7/9 (77.8)
		6‒10	19/61 (31.1)		0‒5		14/19 (73.7)	0‒5	12/14 (85.7)
								6‒10	2/14 (14.3)
					6‒10		5/19 (26.3)	0‒5	1/5 (20.0)
								6‒10	4/5 (80.0)
		Missing	1/61 (1.6)		0‒5		1/1 (100.0)	0‒5	1/1 (100.0)
Missing	1	0‒5	1/1 (100.0)		0‒5		1/1 (100.0)	6‒10	1/1 (100.0)
(B) Subgroup analysis
Aqueous-deficient dry eye subtype (n=41)
0‒5	18	0‒5	16/18 (88.9)		0‒5		15/16 (93.8)	0‒5	15/15 (100.0)
					6‒10		1/16 (6.3)	6‒10	1/1 (100.0)
		6‒10	2/18 (11.1)		0‒5		2/2 (100.0)	0‒5	2/2 (100.0)
6‒10	22	0‒5	15/22 (68.2)		0‒5		12/15 (80.0)	0‒5	9/12 (75.0)
								6‒10	3/12 (25.0)
					6‒10		3/15 (20.0)	6‒10	3/3 (100.0)
		6‒10	6/22 (27.3)		0‒5		5/6 (83.3)	0‒5	4/5 (80.0)
								6‒10	1/5 (20.0)
					6‒10		1/6 (16.7)	6‒10	1/1 (100.0)
		Missing	1/22 (4.5)		0‒5		1/1 (100.0)	0‒5	1/1 (100.0)
Missing	1	0‒5	1/1 (100.0)		0‒5		1/1 (100.0)	6‒10	1/1 (100.0)
Evaporative dry eye subtype (n=44)
0‒5	26	0‒5	25/26 (96.2)		0‒5		23/25 (92.0)	0‒5	23/23 (100.0)
					6‒10		2/25 (8.0)	0‒5	1/2 (50.0)
								6‒10	1/2 (50.0)
		6‒10	1/26 (3.8)		0‒5		1/1 (100.0)	0‒5	1/1 (100.0)
6‒10	18	0‒5	14/18 (77.8)		0‒5		9/14 (64.3)	0‒5	7/9 (77.8)
								6‒10	2/9 (22.2)
					6‒10		5/14 (35.7)	0‒5	2/5 (40.0)
								6‒10	3/5 (60.0)
		6‒10	4/18 (22.2)		0‒5		3/4 (75.0)	0‒5	3/3 (100.0)
					6‒10		1/4 (25.0)	0‒5	1/1 (100.0)
Mixed dry eye subtype (n=49)
0‒5	28	0‒5	28/28 (100.0)		0‒5		28/28 (100.0)	0‒5	27/28 (96.4)
								6‒10	1/28 (3.6)
6‒10	21	0‒5	12/21 (57.1)		0‒5		11/12 (91.7)	0‒5	11/11 (100.0)
					6‒10		1/12 (8.3)	6‒10	1/1 (100.0)
		6‒10	9/21 (42.9)		0‒5		6/9 (66.7)	0‒5	5/6 (83.3)
								6‒10	1/6 (16.7)
					6‒10		3/9 (33.3)	6‒10	3/3 (100.0

Notes: Full analysis set n is the number of patients on the respective category at the particular time point. M is the number of patients included in the respective category of the previous time point. Percentages are based on M. Baseline dry eye symptom assessment is obtained prior to dosing.