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. 2020 Sep 16;21(18):6801. doi: 10.3390/ijms21186801

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Gene expression data for BDNF, AIF, and caspase-3 genes in four different brain regions. (A): In the frontal cortex, BDNF mRNA levels were significantly higher in the naïve (untreated) group, but they were very similar in the control-normothermia (C-NT), asphyxia-normothermia (A-NT), and asphyxia-hypothermia (A-HT) groups. AIF and caspase-3 levels were also very similar in all four groups. (B): In the occipital cortex, the mRNA levels of all three genes were significantly elevated in the A-HT group compared to the A-NT group. (C): In the hippocampus, an identical pattern of gene expression was observed. (D): In the caudate nucleus, BDNF and AIF but not caspase-3 mRNA levels were significantly increased in the A-HT group compared to the A-NT group. Lines, boxes, whiskers, and bullets represent the median, the interquartile range, the 10th–90th percentiles, and raw data, respectively. * vs. A-NT p < 0.05.