Figure 1.

A simplified schematic of key metabolic pathways. Cancer cells alter key enzymes in metabolic pathways, including glycolysis, tricarboxylic acid (TCA) cycle, electron transport chain and lipid metabolism to promote cancer cell survival and proliferation. ACACA, acetyl-CoA carboxylase α; ACLY, ATP citrate lyase; ENO, enolase; FASN, fatty acid synthase; FH, fumarate hydratase; HK, hexokinase; LDH, lactate dehydrogenase; OGDH, oxoglutarate dehydrogenase; PDH, pyruvate dehydrogenase; PDK, pyruvate dehydrogenase kinase; PFK, phosphofructokinase; PFKFB2, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; PK, pyruvate kinase; SDH, succinate dehydrogenase.