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. 2020 Sep 10;21(18):6622. doi: 10.3390/ijms21186622

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Roles of Tip60 in cancer metabolism. Tip60 influences cell fate in metabolic adaptations of cancer cells indirectly by impacting on transcriptional activities of c-Myc, hypoxia inducible factor 1α (HIF-1α) and p53. Tip60 contributes to the metabolic plasticity of cancer cells upon metabolic stress by inducing the activities of glycolytic and gluconeogenic enzymes directly. ENO1, enolase 1; GLUT1, glucose transporter 1; HK2, hexokinase 2; PDK1, pyruvate dehydrogenase kinase 1; LDH-A, lactate dehydrogenase A; PEPCK1, phosphoenolpyruvate carboxykinase 1; PFK, phosphofructokinase; PKM2, pyruvate kinase isoform M2; VEGF, vascular endothelial growth factor.