Table 1.

Inhibitors Used in the Transport Study

Inhibitor	Concentration	Function
Act D	3.2 μM	Inhibitor of ASBT-mediated transport
CFZ	10 µM	Inhibitor of OSTα/β
Chlorpromazine	32 μM	Inhibitor of clathrin-mediated endocytosis
MBCD	10 mM	Inhibitor of caveola/lipid raft-mediated endocytosis (cholesterol depletion agent)
Genistein	0.1 mM	Inhibitor of caveola/lipid raft-mediated endocytosis (nonspecific inhibitor of protein tyrosine kinase)
Amiloride	0.1 mM	Inhibitor of macropinocytosis
Cys A	10 µM	Inhibitor of P-gp-mediated efflux
Brefeldin A	90 µM	Inhibitor of the ER/Golgi pathway

Abbreviations: Act D, actinomycin D; ASBT, apical sodium-dependent bile acid transporter; CFZ, clofazimine; OST_α/β, organic solute transporter alpha/beta; MBCD, methyl-β-cyclodextrin; Cys A, cyclosporine A; P-gp, P-glycoprotein; ER, endoplasmic reticulum.