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. 2020 Oct 9;15:7719–7743. doi: 10.2147/IJN.S267424

Table 2.

Effective and Apparent Permeabilities of OP, OP/DLM, OP-SF, and ODSF

Test Materials Effective Permeability
(Pe, ×10−6, cm/s)		 Apparent Permeability
(Papp, ×10−6, cm/s)
OP 0.448±0.192 1.55±0.600
OP/DLM 5.56±0.140*** 7.53±1.63***
OP-SF 2.87±0.149***,### 3.07±2.06###
ODSF 10.8±0.56***,###,$ 17.2±0.945***,###,$

Notes: Statistics: one-way ANOVA followed by the Tukey multiple comparisons test. Effective permeability (Pe) values of OP, OP/DLM, OP-SF, and ODSF through an artificial intestinal membrane. Apparent permeability (Papp) values of OP, OP/DLM, OP-SF, and ODSF across a Caco-2 cell monolayer. Each value is mean±standard deviation (n=6). ***P<0.001, compared to OP; ###P<0.001, compared to OP/DLM; $P<0.001, compared to OP-SF.

Abbreviations: OP, oxaliplatin; DLM, Nα-deoxycholyl-l-lysyl-methylester; OP/DLM, ion-pairing complex between OP and DLM; P188, poloxamer 188; OP-SF, solid oral formulation of OP with P188 and Labrasol; ODSF, solid oral formulation of OP/DLM with P188 and Labrasol.