Table 2.

Models of hemorrhagic stroke generated in swine. Abbreviation; MRgFUS, magnetic resonance-guided focused ultrasound.

Type of Approach	Approach	Method	Target	Advantages	Disadvantages	References
Intracranial hemorrhage	Craniotomy	MRgFUS	Brain parenchyma	(1) Reproducible	(1) Invasive	[160]
		Collagenase injection	Brain parenchyma	(1) Reproducible	(1) Invasive	[161,162,163,164]
					(2) Only used in juvenile pigs
		Single blood injection	Brain parenchyma	(1) Reproducible	(1) Invasive	[165]
	Transcranial	MRgFUS	Brain parenchyma	(1) Reproducible (2) Minimally invasive	(1) Target limitation	[166,167]
	Cranial burr hole	Double blood injection	Brain parenchyma	(1) Reproducible	(1) Relatively invasive	[51,69,168,169,170,171]
		Balloon catheter dilation and double blood injection	Brain parenchyma	(1) Reproducible	(1) Relatively invasive	[172,173,174,175,176,177,178,179,180,181,182]
		Balloon catheter dilation and single blood injection	Brain parenchyma	(1) Reproducible	(1) Relatively invasive	[183,184,185,186]
		Single blood injection	Ventricle	(1) Reproducible	(1) Relatively invasive	[158,159,187,188,189,190,191,192,193,194,195,196,197,198,199,200,201,202,203,204,205,206,207,208,209,210,211,212]
			Brain parenchyma
Meningeal hemorrhage	Transorbital	Single blood injection	Subarachnoid space	(1) Reproducible (2) Minimally invasive	(1) Technically difficult	[213]
	Cranial burr hole	Single blood injection	Subarachnoid space	(1) Reproducible	(1) Relatively invasive	[214,215]
	Craniotomy	Single blood injection	Subarachnoid space	(1) Reproducible	(1) Invasive	[157,216,217,218,219,220]
		Balloon catheter dilation and single blood injection	Epidural space	(1) Reproducible	(1) Invasive	[221,222]
	Intrathecal	Single blood injection	Cisterna magna (subarachnoid space)	(1) Reproducible		[223,224,225,226]
				(2) Minimally invasive
	Laminectomy	Single blood injection	Pontine cistern (subarachnoid space)	(1) Reproducible	(1) Invasive	[227,228,229]