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. 2020 Oct 13;10:17078. doi: 10.1038/s41598-020-74022-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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BPC 157 activated the Src-Cav-1-eNOS signaling pathway and reduced Cav-1-eNOS interaction. HUVECs were stimulated with 1 μg/ml BPC 157 for different time periods as indicated and the phosphorylation of Src (Tyr 416), Cav-1 (Tyr14) and eNOS (Ser 1177) was analyzed by western blot. Representative blots were shown in (a) and bands were scanned and quantified by densitometric analysis in (b). Data were shown as mean ± SEM of three independent experiments (*means compared with control, p value < 0.05; #means BPC 157 + SKI-1 compared with BPC 157 at same treatment period, p value < 0.05). The Co-IP was also used to assess the interaction between Cav-1 and eNOS. The representative blot and band quantified by densitometric analysis were shown in (c) and (d) respectively (*means compared with control p value < 0.05).