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. 2020 Oct 13;10:17164. doi: 10.1038/s41598-020-73723-8

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Triacylglycerols and diacylglycerols differentiate subjects with low IS level in the fasting state. Box blots presents top ten metabolites showing significant association with the levels of IS. The p-value was defined by the statistical contrast between estimated metabolite levels and IS [low (L) and high (H)] at subjects’ baseline (T1), depicted by “*”. Gray and green color gradient indicate metabolite levels after overnight fasting and hyperinsulinemic-euglycemic clamp, respectively. Light color tone indicate subjects with low IS and dark color tone indicate subjects with high IS.