Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Oct 13;10:17164. doi: 10.1038/s41598-020-73723-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Different metabolic responses to insulin under hyperinsulinemic-euglycemic clamp in clinically healthy subjects replicate in independent cohort consist of T2D (A–E). Box blots presents metabolites showing FDR significantly different responses to HIEC, associated with the levels of IS. The p-value was defined by the statistical contrast under hyperinsulinemic-euglycemic clamp (T2), between estimated metabolite levels and IS [low (L) and high (H)] in clinically healthy or between estimated metabolite levels and insulin-resistance/insulin-sensitive group in replication cohort of T2D. Gray and green color gradient indicate metabolite levels after overnight fasting and hyperinsulinemic-euglycemic clamp, respectively. Light color tone indicate subjects with low IS and dark color tone indicate subjects with high IS. The replication cohort is depicted by blue (fasting-state) and orange (at HIEC) color. Light blue—insulin resistant (R), dark blue—insulin-sensitive (S), light orange—insulin resistant (R), dark orange—insulin sensitive (S).