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. 2020 Sep 17;21(18):6832. doi: 10.3390/ijms21186832

Table 1.

Significantly deregulated proteins in irradiated cardiac left ventricle proteome. The proteins listed in the table were identified and quantified by two or more unique peptides; fold changes and p-values are shown.

Accession ID Annotation Fold Changes p-Value
P00746 CFD Complement factor D 9.3 7.86 × 10−3
Q96PD5 PGLYRP2 N-acetylmuramoyl-L-alanine amidase 7.7 9.62 × 10−3
P04745 AMY1B Amylase, alpha 1B 7.3 4 × 10−2
Q96JB5 CDK5RAP3 CDK5 regulatory subunit-associated protein 3 6.3 3.31 × 10−4
P34897 SHMT2 Serine hydroxymethyltransferase, mitochondrial 6.0 2.99 × 10−2
Q9BQE5 APOL2 Apolipoprotein L2 5.8 3.82 × 10−5
P20700 LMNB1 Lamin-B1 5.7 1.87 × 10−2
P05452 CLEC3B Tetranectin 5.6 4.23 × 10−2
O60784 TOM1 Target of Myb protein 1 4.4 1.10 × 10−2
Q6ICL3 TANGO2 Transport and golgi organization 2 homolog 3.7 2.41 × 10−2
Q08209 PPP3CA Serine/threonine-protein phosphatase 2B catalytic alpha 3.4 2.22 × 10−2
P37802 TAGLN2 Transgelin-2 3.3 1.67 × 10−3
Q01518 CAP1 Adenylyl cyclase-associated protein 1 3.3 1.84 × 10−5
A0A0A0MS15 IGHV3-49 Immunoglobulin heavy variable 3-49 3.2 1.98 × 10−2
P13591 NCAM1 Neural cell adhesion molecule 1 3.1 4.16 × 10−2
O95336 PGLS 6-phosphogluconolactonase 3.1 3.25 × 10−2
Q99715 COL12A1 Collagen alpha-1(XII) chain 3.1 2.22 × 10−2
O95865 DDAH2 N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 3.0 5.28 × 10−3
Q5T0D9 TPRG1L Tumor protein p63 regulated 1 like 3.0 3.05 × 10−4
P31327 CPS1 Carbamoyl-phosphate synthase, mitochondrial 2.9 3.27 × 10−2
P07738 BPGM Bisphosphoglycerate mutase 2.9 1.28 × 10−2
P61221 ABCE1 ATP-binding cassette sub-family E member 1 2.9 4.21 × 10−2
Q7Z3Y8 KRT27 Keratin, type I cytoskeletal 27 2.7 4.64 × 10−3
Q16610 ECM1 Extracellular matrix protein 1 2.7 3.03 × 10−2
P05156 CFI Complement factor I 2.7 1.41 × 10−2
P01780 IGHV3-7 Immunoglobulin heavy variable 3-7 2.6 1.14 × 10−2
P05546 SERPIND1 Heparin cofactor 2 2.6 5.00 × 10−2
O75122 CLASP2 CLIP-associating protein 2 2.6 4.21 × 10−2
Q2TAA2 IAH1 Isoamyl acetate-hydrolyzing esterase 1 homolog 2.5 3.13 × 10−2
P16070 CD44 CD44 antigen 2.4 4.01 × 10−3
P49721 PSMB2 Proteasome subunit beta type-2 2.4 6.87 × 10−7
P13667 PDIA4 Protein disulfide-isomerase A4 2.4 6.55 × 10−3
P35858 IGFALS Insulin-like growth factor-binding protein complex acid labile 2.3 3.50 × 10−2
P19652 ORM2 Alpha-1-acid glycoprotein 2 2.3 2.06 × 10−2
O96007 MOCS2 Molybdopterin synthase catalytic subunit 2.3 8.91 × 10−4
P08294 SOD3 Extracellular superoxide dismutase [Cu-Zn] 2.2 5.01 × 10−2
Q6FI13 HIST2H2AA Histone cluster 2 H2A family member a4 2.2 3.55 × 10−3
P00488 F13A1 Coagulation factor XIII A chain 2.2 3.71 × 10−3
P02649 APOE Apolipoprotein E 2.2 3.95 × 10−2
Q9HBI1 PARVB Beta-parvin 2.2 1.49 × 10−2
Q9BR76 CORO1B Coronin-1B 2.1 1.26 × 10−2
P28074 PSMB5 Proteasome subunit beta type-5 2.1 9.94 × 10−4
P01714 IGLV3-19 Immunoglobulin lambda variable 3-19 2.0 1.91 × 10−2
O60888 CUTA Protein CutA 2.0 1.25 × 10−2
Q16658 FSCN1 Fascin 2.0 3.42 × 10−2
Q9ULV4 CORO1C Coronin-1C 2.0 1.02 × 10−2
P17655 CAPN2 Calpain-2 catalytic subunit 2.0 1.58 × 10−2
Q15582 TGFBI Transforming growth factor-beta-induced protein ig-h3 2.0 3.83 × 10−2
P15144 ANPEP Aminopeptidase N 1.9 3.32 × 10−2
P01008 SERPINC1 Antithrombin-III 1.9 2.66 × 10−2
Q96HY7 DHTKD1 Probable 2-oxoglutarate dehydrogenase E1 component 1.9 4.54 × 10−2
P39059 COL15A1 Collagen alpha-1(XV) chain 1.8 3.28 × 10−2
P35754 GLRX Glutaredoxin-1 1.8 4.58 × 10−2
P40121 CAPG Macrophage-capping protein 1.8 2.32 × 10−2
P36269 GGT5 Glutathione hydrolase 5 proenzyme 1.8 3.04 × 10−2
O75340 PDCD6 Programmed cell death protein 6 1.8 9.00 × 10−3
P12109 COL6A1 Collagen alpha-1(VI) chain 1.8 3.09 × 10−2
P19827 ITIH1 Inter-alpha-trypsin inhibitor heavy chain H1 1.7 4.77 × 10−2
P05109 S100A8 Protein S100-A8 1.7 3.47 × 10−2
P36543 ATP6V1E1 V-type proton ATPase subunit E 1 1.7 1.10 × 10−2
P04040 CAT Catalase 1.7 2.98 × 10−2
P12110 COL6A2 Collagen alpha-2(VI) chain 1.7 3.98 × 10−2
P62191 PSMC1 26S proteasome regulatory subunit 4 1.7 3.55 × 10−2
Q16647 PTGIS Prostacyclin synthase 1.6 2.95 × 10−2
Q9NZN3 EHD3 EH domain-containing protein 3 1.6 6.77 × 10−3
Q9UJZ1 STOML2 Stomatin-like protein 2, mitochondrial 1.6 2.81 × 10−2
P25786 PSMA1 Proteasome subunit alpha type-1 1.6 3.65 × 10−2
Q8IUE6 HIST2H2AB Histone H2A type 2-B 1.5 1.13 × 10−2
Q13084 MRPL28 Mitochondrial ribosomal protein L28 1.5 5.01 × 10−2
Q13162 PRDX4 Peroxiredoxin-4 1.5 3.24 × 10−2
Q9Y490 TLN1 Talin-1 1.5 2.94 × 10−2
Q15121 PEA15 Astrocytic phosphoprotein PEA-15 1.5 3.16 × 10−2
Q9H4M9 EHD1 EH domain-containing protein 1 1.5 1.64 × 10−2
O75396 SEC22B Vesicle-trafficking protein SEC22b 1.5 7.62 × 10−3
P24821 TNC Tenascin 1.4 4.70 × 10−3
P02766 TTR Transthyretin 1.4 4.35 × 10−3
P02042 HBD Hemoglobin subunit delta 1.4 2.66 × 10−2
P78527 PRKDC DNA-dependent protein kinase catalytic subunit 1.4 4.48 × 10−2
P25788 PSMA3 Proteasome subunit alpha type-3 1.4 4.59 × 10−2
P68871 HBB Hemoglobin subunit beta 1.4 1.54 × 10−2
P07451 CA3 Carbonic anhydrase 3 1.4 4.69 × 10−2
P26447 S100A4 S100 calcium binding protein A4 1.4 9.24 × 10−3
P0C0S5 H2AFZ Histone H2A.Z 1.4 1.23 × 10−2
P51398 DAP3 28S ribosomal protein S29, mitochondrial 1.4 4.85 × 10−4
P28072 PSMB6 Proteasome subunit beta type-6 1.4 3.67 × 10−2
P23284 PPIB Peptidyl-prolyl cis-trans isomerase B 1.4 2.32 × 10−2
P04196 HRG Histidine-rich glycoprotein 1.3 4.56 × 10−2
Q14697 GANAB Neutral alpha-glucosidase AB 1.3 4.40 × 10−2
P00915 CA1 Carbonic anhydrase 1 1.3 1.55 × 10−2
Q96QK1 VPS35 Vacuolar protein sorting-associated protein 35 1.3 2.98 × 10−2
P69905 HBA2 Hemoglobin subunit alpha 2 1.3 3.55 × 10−2
P35613 BSG Basigin 0.76 7.53 × 10−3
P51649 ALDH5A1 Succinate-semialdehyde dehydrogenase, mitochondrial 0.76 2.80 × 10−2
P62263 RPS14 Ribosomal protein S14 0.76 4.03 × 10−2
P09429 HMGB1 High mobility group protein B1 0.76 5.01 × 10−2
Q9H7Z7 PTGES2 Prostaglandin E synthase 2 0.76 3.68 × 10−2
Q9Y2Z9 COQ6 Ubiquinone biosynthesis monooxygenase COQ6 0.75 1.62 × 10−2
Q8NDY3 ADPRHL1 [Protein ADP-ribosylarginine] hydrolase-like protein 1 0.75 4.76 × 10−2
Q7Z406 MYH14 Myosin-14 0.75 4.69 × 10−2
Q16698 DECR1 2,4-dienoyl-CoA reductase, mitochondrial 0.75 4.16 × 10−2
Q03252 LMNB2 Lamin-B2 0.75 8.66 × 10−3
P10916 MYL2 Myosin regulatory light chain 2, ventricular/cardiac 0.75 2.03 × 10−2
Q0ZGT2 NEXN Nexilin 0.74 4.74 × 10−2
E7EW31 PROB1 Proline rich basic protein 1 0.74 4.33 × 10−2
P52179 MYOM1 Myomesin-1 0.73 8.85 × 10−3
Q9Y265 RUVBL1 RuvB-like 1 0.73 3.98 × 10−2
P46777 RPL5 60S ribosomal protein L5 0.73 3.86 × 10−3
P30038 ALDH4A1 Delta-1-pyrroline-5-carboxylate dehydrogenase 0.73 2.60 × 10−2
P32119 PRDX2 Peroxiredoxin-2 0.73 2.77 × 10−2
P45379 TNNT2 Troponin T, cardiac muscle 0.73 8.78 × 10−3
O75521 ECI2 Enoyl-CoA delta isomerase 2, mitochondrial 0.72 4.43 × 10−2
Q16836 HADH Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial 0.72 1.58 × 10−2
Q9BTZ2 DHRS4 Dehydrogenase/reductase SDR family member 4 0.72 1.67 × 10−2
P07339 CTSD Cathepsin D 0.72 1.31 × 10−3
Q9BX66 SORBS1 Sorbin and SH3 domain-containing protein 1 0.72 3.43 × 10−2
Q15046 KARS Lysine—tRNA ligase 0.71 2.49 × 10−2
O75438 NDUFB1 NADH dehydrogenase [ubiquinone] 1 beta subcomplex 1 0.71 1.62 × 10−2
O95817 BAG3 BAG family molecular chaperone regulator 3 0.71 3.99 × 10−2
Q9UL25 RAB21 Ras-related protein Rab-21 0.71 3.92 × 10−2
P21397 MAOA Amine oxidase [flavin-containing] A 0.70 7.04 × 10−3
Q96HS1 PGAM5 Serine/threonine-protein phosphatase PGAM5 0.70 1.43 × 10−2
Q9Y5J7 TIMM9 Mitochondrial import inner membrane translocase 0.70 1.36 × 10−2
O75947 ATP5H ATP synthase subunit d, mitochondrial 0.70 2.39 × 10−2
P19429 TNNI3 Troponin I, cardiac muscle 0.69 9.61 × 10−3
P62753 RPS6 40S ribosomal protein S6 0.69 2.02 × 10−2
Q13045 FLII Protein flightless-1 homolog 0.69 1.78 × 10−2
O95292 VAPB Vesicle-associated membrane protein-associated protein 0.68 1.72 × 10−2
P02511 CRYAB Alpha-crystallin B chain 0.67 3.99 × 10−3
P15121 AKR1B1 Aldose reductase 0.67 5.01 × 10−2
Q9NUJ1 ABHD10 Mycophenolic acid acyl-glucuronide esterase 0.67 1.49 × 10−3
P46779 RPL28 60S ribosomal protein L28 0.67 3.76 × 10−2
Q6PIU2 NCEH1 Neutral cholesterol ester hydrolase 1 0.67 4.07 × 10−2
Q8WWI1 LMO7 LIM domain only protein 7 0.66 5.01 × 10−2
Q9UFN0 NIPSNAPA Nipsnap homolog 3A 0.66 2.13 × 10−3
Q14118 DAG1 Dystroglycan 0.66 7.65 × 10−3
Q5BKX8 MURC Caveolae-associated protein 4 0.65 1.78 × 10−3
Q6IAA8 LAMTOR1 Ragulator complex protein LAMTOR1 0.65 2.14 × 10−2
O43676 NDUFB3 NADH dehydrogenase [ubiquinone] 1 beta subcomplex 3 0.65 3.38 × 10−2
P49368 CCT3 T-complex protein 1 subunit gamma 0.64 1.01 × 10−2
P63220 RPS21 Ribosomal protein S21 0.64 1.14 × 10−2
Q9UMR2 DDX19B ATP-dependent RNA helicase DDX19B 0.64 5.87 × 10−5
Q8NBN7 RDH13 Retinol dehydrogenase 13 0.64 4.74 × 10−2
Q14192 FHL2 Four and a half LIM domains protein 2 0.64 5.01 × 10−2
O76024 WFS1 Wolframin 0.64 4.83 × 10−2
P30084 ECHS1 Enoyl-CoA hydratase, mitochondrial 0.63 5.17 × 10−3
Q9HBL7 PLGRKT Plasminogen receptor (KT) 0.63 2.44 × 10−2
P26440 IVD Isovaleryl-CoA dehydrogenase, mitochondrial 0.63 2.67 × 10−2
P60866 RPS20 Ribosomal protein S20 0.62 3.18 × 10−2
Q6DN03 HIST2H2BC Putative histone H2B type 2-C 0.62 1.71 × 10−2
Q99460 PSMD1 26S proteasome non-ATPase regulatory subunit 1 0.61 1.71 × 10−2
Q96PE7 MCEE Methylmalonyl-CoA epimerase, mitochondrial 0.61 1.44 × 10−2
Q8N3J5 PPM1K Protein phosphatase 1K, mitochondrial 0.61 2.98 × 10−2
Q9Y5K5 UCHL5 Ubiquitin carboxyl-terminal hydrolase isozyme L5 0.61 1.82 × 10−4
Q9H987 SYNPO2L Synaptopodin 2-like protein 0.60 2.82 × 10−2
O95182 NDUFA7 NADH dehydrogenase [ubiquinone] 1 alpha 7 0.59 8.36 × 10−3
Q9NQR4 NIT2 Omega-amidase NIT2 0.59 1.48 × 10−2
Q96ND0 FAM210A Protein FAM210A 0.58 3.74 × 10−2
P46109 CRKL Crk-like protein 0.58 2.56 × 10−2
Q13409 DYNC1I2 Cytoplasmic dynein 1 intermediate chain 2 0.57 9.61 × 10−3
P62906 RPL10A 60S ribosomal protein L10a 0.57 1.81 × 10−2
Q8NF91 SYNE1 Nesprin-1 0.57 2.02 × 10−2
O94875 SORBS2 Sorbin and SH3 domain-containing protein 2 0.56 2.55 × 10−2
Q9BS92 NIPSNAP3B Nipsnap homolog 3B 0.56 5.01 × 10−2
Q13151 HNRNPA0 Heterogeneous nuclear ribonucleoprotein A0 0.55 1.94 × 10−2
P82675 MRPS5 Mitochondrial ribosomal protein S5 0.55 1.17 × 10−2
P22830 FECH Ferrochelatase, mitochondrial 0.55 9.32 × 10−3
Q5HYJ1 TECRL trans-2,3-enoyl-CoA reductase like 0.55 4.59 × 10−3
Q9Y285 FARSA phenylalanyl-tRNA synthetase alpha subunit 0.54 2.10 × 10−4
Q8TB22 SPATA20 Spermatogenesis-associated protein 20 0.53 4.46 × 10−3
Q9NP72 RAB18 Ras-related protein Rab-18 0.52 4.87 × 10−3
O75190 DNAJB6 DnaJ homolog subfamily B member 6 0.52 8.53 × 10−3
P35542 SAA4 Serum amyloid A-4 protein 0.51 3.04 × 10−2
E9PAV3 NACA Nascent polypeptide-associated complex subunit alpha 0.49 5.23 × 10−5
Q8N6M3 FITM2 Fat storage-inducing transmembrane protein 2 0.48 1.85 × 10−2
P27816 MAP4 Microtubule-associated protein 4 0.47 4.48 × 10−2
P0CAP1 MYZAP Myocardial zonula adherens protein 0.47 1.87 × 10−2
Q96AB3 ISOC2 Isochorismatase domain containing 2 0.46 9.70 × 10−3
Q562R1 ACTBL2 Beta-actin-like protein 2 0.44 3.63 × 10−2
Q9NS69 TOMM22 Mitochondrial import receptor subunit TOM22 homolog 0.43 1.34 × 10−2
Q9BXK5 BCL2L13 Bcl-2-like protein 13 0.42 2.93 × 10−2
Q16543 CDC37 Hsp90 co-chaperone Cdc37 0.42 5.00 × 10−2
P43155 CRAT Carnitine O-acetyltransferase 0.42 1.24 × 10−3
Q5VWP3 MLIP Muscular LMNA-interacting protein 0.41 3.38 × 10−2
O60488 ACSL4 Long-chain-fatty-acid—CoA ligase 4 0.40 2.89 × 10−4
Q08722 CD47 Leukocyte surface antigen CD47 0.39 6.97 × 10−3
Q6Y288 B3GALTL Beta-1,3-glucosyltransferase 0.38 4.29 × 10−3
P43487 RANBP1 Ran-specific GTPase-activating protein 0.35 1.93 × 10−6
P01040 CSTA Cystatin-A 0.33 3.50 × 10−2
P48506 GCLC Glutamate—cysteine ligase catalytic subunit 0.33 4.30 × 10−2
P08621 SNRNP70 U1 small nuclear ribonucleoprotein 70 kDa 0.30 2.09 × 10−3
P23919 DTYMK Thymidylate kinase 0.30 6.33 × 10−3
O95394 PGM3 Phosphoacetylglucosamine mutase 0.29 4.82 × 10−2
P12829 MYL4 Myosin light chain 4 0.26 2.84 × 10−4
Q9NX40 OCIAD1 OCIA domain-containing protein 1 0.19 1.96 × 10−3
Q08830 FGL1 Fibrinogen-like protein 1 0.12 4.76 × 10−3
Q08397 LOXL1 Lysyl oxidase homolog 1 0.08 2.20 × 10−2