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. 2020 Sep 10;9(9):850. doi: 10.3390/antiox9090850

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effect of subcutaneous injection of increasing doses of LMW-DS (ILB^®) on the cerebral concentrations of GTP (A), UTP (B), and CTP (C), as valuable indicators of the nervous cell energy state. The parameters of interest were determined by HPLC on deproteinized cerebral homogenates at 2 and 7 days post-impact, both in untreated sTBI rats (TBI 2 days and TBI 7 days) and in rats receiving 1, 5, or 15 mg/kg b.w. LMW-DS (ILB^®) administered 30 min after sTBI. Controls are represented by sham-operated rats. Values are the mean ± SD of 12 different animals and are expressed as nmol/g w.w. * Significantly different from sham-operated control rats, p < 0.05. # Significantly different from the corresponding time point of untreated sTBI rats, p < 0.05.