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. 2020 Sep 20;21(18):6902. doi: 10.3390/ijms21186902

Figure 3.

Figure 3

The impact of redox imbalance on canonical pathway of miRNAs biogenesis. For more detailed description see Section 3. Stimulatory interactions are indicated by arrows (except for the sharp black arrows) and inhibition by T-bars. Arrows which are crossed out denote the withdrawal of the stimulation. Red interactions and crosses mark the impact of oxidative stress. Processes/phenomena, elements concerning subsequent stages of produced miRNA, side product of miRNA biogenesis, proteins/compounds are highlighted in blue, yellow, grey and green, respectively. The figure was made using the PathVisio 3.3.0 free open-source software [64]. miRNA—microRNA, pri-miRNA—primary microRNA, pre-miRNA—premature microRNA, Ran-GTP—Ras-related nuclear protein-guanosine-5’-triphosphate, GSK3β—glycogen synthase kinase 3 beta, Drosha—Drosha class 2 Ribonuclease III, DICER—Dicer 1, Ribonuclease III, RISC—RNA-induced silencing complex, IRE1α—inositol-requiring enzyme 1 α.