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. 2020 Sep 15;21(18):6751. doi: 10.3390/ijms21186751

Figure 3.

Figure 3

Iron-uptake and ferritinophagy-related gene expression are not affected by TP53 mutation status or erastin treatment. Relative mRNA expression of (A) transferrin receptor 1 (TFRC) (B) nuclear receptor coactivator 4 (NCOA4), (C) autophagy related 5 (ATG5), (D) CDGSG iron sulfur domain 1 (CISD1), and (E) solute carrier family 7 member 11 (SLC7A11) in TP53 null H1299 cells (H1299) or H1299 cells transfected with wild-type (WT) TP53, or the indicated TP53 mutant (n = 3 per cell type and treatment group). Relative mRNA expression of (F) TFRC, (G) NCOA4, (H) ATG5, (I) CISD1, and (J) SLC7A11 in TP53 null H1299 cells (H1299) or H1299 cells transfected with wild-type (WT) TP53, or the indicated mutant TP53 following treatment with DMSO (control) or 10 µM erastin for 24 h. a Denotes statistical difference from H1299. * Denotes statistical differences from respective control, p < 0.05. Error bars indicate SEM.