Table 1.

The role of miRNAs to modulate specific genes and mRNA of various risk factors of ischemic stroke.

miRNA	Target Gene	Process	Effects Produced by Modulating mRNA Role
miR-126	VCAM1 [22]	Atherosclerosis	Reduced neutrophil infiltration
miR-155	PU.1 [23]	Arterial hypertension	Reduced monocyte maturation
miR-155	SOCS1 [24]	Inflammation	Suppression of inflammation
miR-125b	NR2A [25]	Excitotoxicity	Decreased NMDA activation
miR-125b	p53 [26]	Neuronal death	Reduced neuronal death
miR-146a	IRAK-1, IL-6, IL-8 [27]	Inflammation	Reduced inflammation
miR-145	KLP4, KLP5 [28]	Atherosclerosis	Promotes SMC growth
Let-7a	Casp3 [22]	Apoptosis	Reduced apoptosis
miR-221	KIT [29]	Type 2 Diabetes	Endothelial dysfunction
miR-221	KIP1 [29]	Atherosclerosis	Promotes SMC growth
miR-222	KIP2 [29]	Atherosclerosis	Promotes SMC growth
miR-223	NR2A [30]	Excitotoxicity	Increased NMDA activation
miR-424	NRF2 [31]	Inflammation	Reduced inflammation
miR-181a miR-25	Bim (BCL2L11) [32]	Apoptosis	Reduced apoptosis
miR-29b, miR-130a	AQP4 [33,34]	Edema	Reduces edema formation
miR-29b, miR-15	Bcl-2 [35,36]	Apoptosis	Reduced apoptosis

SMC—smooth muscle cells.