Table 2.
The specific role of miRNAs modulating several target genes involved in post-ischemic inflammation.
| miRNA | Target | mRNA Activity | Effects Produced by Modulating mRNA Role |
|---|---|---|---|
| miR-424 | NRF2 [31] | Increase | Suppression of inflammation |
| miR-let- 7c-5p | Casp3 [115] | Decrease | Suppression of inflammation |
| miR-124 | C/EBP-α-PU.1 [125] | Decrease | Suppression of inflammation |
| miR-155 | SOCS1, MyD88 [24] | Decrease | Suppression of inflammation |
| miR-106a | IL-10 [27] | - | Suppression of inflammation |
| miR-146a | IL-6, IL-1β [27] | Decrease | Suppression of inflammation |
| miR-9 | MMP-9, MMP-13 [115] | Decrease | Suppression of inflammation |
| miR-219 | MPP9 [31] | Decrease | Suppression of inflammation |
| miR-181c | TLR4 [120] | Increase | Suppression of inflammation |
| miR-181a | IL1 [122] | Increase | Suppression of inflammation |
MMP—matrix metalloproteinase, IL—interleukin, TLR—Toll-like receptors, SOCS1—Suppressor of cytokine signaling 1.