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. 2020 Sep 22;21(18):6971. doi: 10.3390/ijms21186971

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of 4-AAQB on the osteoclastogenesis signaling pathway. Osteoclastogenesis proteins were assayed by western blotting after exposure to v-Xg (A) conditions for 24 h. The cells were treated with 4-AAQB (1, 3, or 10 µM) or ALN (10 µM) combined with RANKL for 54 h. The quantitative results of NFATc1 (B), c-Fos (C), and DC-STAMP (D) represent the mean ± SEM (n = 3). In addition, after exposure to μXg (E) conditions for 24 h, the cells were treated under the same stimulation conditions as the v-Xg group for 48 h. The quantitative results (F–H) represent the mean ± SEM (n = 3). * p < 0.05, ^**p < 0.01 and *** p < 0.001 versus control; # p < 0.05, ## p < 0.01, and ### p < 0.001 versus RANKL.

Effects of 4-AAQB on the osteoclastogenesis signaling pathway. Osteoclastogenesis proteins were assayed by western blotting after exposure to v-Xg (A) conditions for 24 h. The cells were treated with 4-AAQB (1, 3, or 10 µM) or ALN (10 µM) combined with RANKL for 54 h. The quantitative results of NFATc1 (B), c-Fos (C), and DC-STAMP (D) represent the mean ± SEM (n = 3). In addition, after exposure to μXg (E) conditions for 24 h, the cells were treated under the same stimulation conditions as the v-Xg group for 48 h. The quantitative results (F–H) represent the mean ± SEM (n = 3). * p < 0.05, ^**p < 0.01 and *** p < 0.001 versus control; # p < 0.05, ## p < 0.01, and ### p < 0.001 versus RANKL.