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. 2020 Sep 22;21(18):6971. doi: 10.3390/ijms21186971

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of 4-AAQB on osteoclast apoptosis and the cell cycle after μXg stimulation. After exposure to μXg (A) conditions for 24 h, the cells were treated with 4-AAQB or ALN combined with RANKL for 48 h. Apoptotic proteins were assayed by western blotting. The quantitative results of cleaved PARP (B), cleaved caspase-8 (C), cleaved caspase-9 (D), and cleaved caspase-3 (E) represent the mean ± SEM (n = 3). In addition, the cell cycle proteins were also assayed by western blotting (F). The quantitative results of p53 (G), p21 (H), cyclin D3 (I), and cyclin E1 (J) represent the mean ± SEM (n = 3). * p < 0.05, ** p < 0.01, and *** p < 0.001 versus control; # p < 0.05, ## p < 0.01, and ### p < 0.001 versus RANKL.

Effects of 4-AAQB on osteoclast apoptosis and the cell cycle after μXg stimulation. After exposure to μXg (A) conditions for 24 h, the cells were treated with 4-AAQB or ALN combined with RANKL for 48 h. Apoptotic proteins were assayed by western blotting. The quantitative results of cleaved PARP (B), cleaved caspase-8 (C), cleaved caspase-9 (D), and cleaved caspase-3 (E) represent the mean ± SEM (n = 3). In addition, the cell cycle proteins were also assayed by western blotting (F). The quantitative results of p53 (G), p21 (H), cyclin D3 (I), and cyclin E1 (J) represent the mean ± SEM (n = 3). * p < 0.05, ** p < 0.01, and *** p < 0.001 versus control; # p < 0.05, ## p < 0.01, and ### p < 0.001 versus RANKL.