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. 2020 Sep 19;21(18):6884. doi: 10.3390/ijms21186884

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Overexpression of miR-29a alleviated mitochondrial proteostasis stress. (A) Misfolded protein aggregation in live tissue was stained by thioflavin T (ThT). White open inserts in the upper panel are enlarged in the lower panel. Scale bar, 100 μm. Mean fluorescence intensity (MFI) of ThT was determined using Image J. N = 6–8 in each group. a.u., arbitrary unit. (B) Representative blots and densitometric results of p-PERK, IRE1α and XBP1s, indicators of unfolded protein response of the endoplasmic reticulum (UPR^ER). N = 6 in each group. (C) Representative blots and densitometric results of CHOP, LONP1, and HSP60, indicators of unfolded protein response of the mitochondria (UPR^mt). N = 6 in each group. Data are expressed as mean ± SE. * p < 0.05 between indicated groups. MCD, methionine/choline-deficient; MCS, methionine/choline-sufficient.