Figure 16.

The administration of low doses of DBT, but not thiamine prevents the stress-induced increase of helpless behavior in mice. In the forced swim test, in comparison to control group, ultrasound-exposed vehicle-treated mice and stressed mice treated with thiamine at the dose of 5 mg/kg/day showed a significant increase of the total duration of floating. Ultrasound-exposed groups treated with thiamine at the dose of 200 mg/kg/day and DBT at the dose of 25 or 200 mg/kg/day displayed significantly shorter duration of this behavior than vehicle-treated mice exposed to the ultrasound stress (*, p < 0.05 vs. nontreated control mice, #, p < 0.05 vs. vehicle-treated ultrasound-exposed group, one-way ANOVA and post hoc Tukey’s test). A total of 6–10 animals per group were used. Doses are expressed in mg/kg per day. Bars are mean ± SEM.