Table 2.

Mean Ratio (MR) and 95% Confidence Interval (C.I.) of 7-hydro-8-oxo-2′-deoxyguanosine (8-oxodG) and 5-hydroxycytosine (5-OHC) at the codon 176 along the exon 5 sequence of the p53 gene among hepatitis C virus (HCV)-associated hepatocellular carcinoma (HCC) patients and controls. MR estimates of 3-(2-deoxy-β-d-erythro-pentafuranosyl)pyrimido[1,2-α]purin-10(3H)-one deoxyguanosine (M₁dG) are shown.

Mean Ratio and 95% Confidence Interval of Biomarkers Under Study
	8-oxodG (–TGC–) a	5-OHC (–TGC–) a	M1dG
	MR, 95% C.I.	MR, 95% C.I.	MR, 95% C.I.
Controls	Reference	Reference	Reference
HCV-HCC patients	2.3, 1.57–3.48	3.8, 0.71–20.3	1.87, 1.27–2.77
p-value b	<0.0001	0.115	0.001

^a Underlined letters indicate the residues for which lesions are reported; ^b p-values referred to comparison with the reference level after correction for age and gender.