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(A) Histology of abdominal subcutaneous adipose tissues stained with H&E (scale bars, 20 μm). Arrows indicate uncoupling protein 1 (UCP1)-positive cells. (B) UCP1-positive cells were significantly more abundant in the FGF21-treated mice than in the control (% of total cells). (C) Histology of brown adipose tissues stained by H&E (scale bars, 20 μm). (D) Comparison of fat cell size (% of control) between the control and the FGF21 group. Data are means ± SD. * p < 0.05 vs. control.
