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The role of NRF2 in mitochondrial regulation of bone homeostasis in MBD. The balance of OCs and OBs is impaired in osteolytic bone lesions, where OB activity is suppressed while the osteoclastogenesis is strongly upregulated. Activation of NRF2 could promote osteoblastogenesis, while restraining uncontrolled osteoclastogenesis. Red arrows indicate active effect; Blue bar arrow indicates suppressive effect.
