Table 1.

Mediators of AngII-dependent senescence in VSMC.

System	Inducer	Signaling	Reference
in vitro	Nox-derived ROS	Nox1/2	[70,71]
in vitro	Nox-derived ROS	MEK/ERK, p38, Akt	[72]
in vitro	Nox-derived ROS	Rac1	[73]
in vitro	Mitochondrial ROS	Complex I/II	[68]
in vitro	Sm22α	PI3K/Akt	[74]
in vivo	p53	Complex IV	[69]
in vivo	Mitochondria fission	Drp1	[75]