Table 2.

Inhibitors of AngII-dependent senescence in VSMC.

System	Inhibitor	Target	Reference
in vitro	PGC1-α/Sirt1	Oxidative stress	[76]
in vitro	Sirt1	Oxidative stress	[82]
in vitro	PKA/Nrf2	Oxidative stress	[78]
in vitro	Klotho/Nrf2	Oxidative stress	[79]
in vitro	PGC1-α	Atg5/autophagy	[77]
in vitro	autophagy	Oxidative stress	[83]
in vivo	Sirt1	p21/AAA	[76,84]
in vivo	Sirt3	Mitochondrial ROS	[76,80]
in vivo	NAD+	DNA damage	[76,81]