Figure 3.

Upregulation of methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 (MTHFD2) was associated with poor clinical outcome of HNSCC in the public datasets. (A) MTHFD2 was overexpressed in HNSCC tumor specimens compared to the paired adjacent normal tissues. (B) MTHFD2 was upregulated in HNSCC tissues compared to the normal controls. (C) High MTHFD2 expression was positively associated with lymph node metastasis. (D) High MTHFD2 expression was positively correlated with tumor grade. (E) Patients in the high MTHFD2 group had worse OS than those in the low MTHFD2 group.