Table 2.
Association between immunohistochemical loss of MMR protein expression and clinical/molecular characteristics.
| All Patients | Patients with Grade III | Patients with Grade IV | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Alteration of MMR Protein Expression: n/N (%) | p-value | Partial:Complete Loss of MMR Protein Expression: n:n | Alteration of MMR Protein Expression: n/N (%) | p-Value | Partial:Complete Loss of MMR Protein Expression: n:n | Alteration of MMR Protein Expression: n/N (%) | p-Value | Partial:Complete Loss of MMR Protein Expression: n:n | |
| No. | 43/355 (12.1) | - | 28:15 | 13/40 (32.5) | - | 9:4 | 30/315 (9.5) | - | 19:11 |
| Females | 15/114 (13.2) | 0.81 | 12:3 | 7/14 (50.0) | 0.17 | 6.1 | 8/100 (8.0) | 0.67 | 6:2 |
| Males | 28/241 (11.6) | 16:12 | 6/26 (23.1) | 3:3 | 22/215 (10.2) | 13:9 | |||
| Grade: | <0.0001 | - | - | - | - | - | - | ||
| III | 13/40 (32.5) | 9:4 | |||||||
| IV | 30/315 (9.5) | 19.11 | |||||||
| Analyzed tissue at: | 0.002 | 0.70 | 0.003 | ||||||
| Diagnosis | 29/301 (9.6) | 20:9 | 9/30 (30.0) | 7:2 | 20/271 (7.4) | 13:7 | |||
| Recurrence | 14/54 (25.9) | 8:6 | 4/10 (40.0) | 2.2 | 10/44 (22.7) | 6:4 | |||
| RT before tissue analysis: | 0.23 | 0.99 | 0.25 | ||||||
| No | 33/299 (11.0) | 24:9 | 10/30 (33.3) | 9:1 | 23/269 (8.6) | 15:8 | |||
| Yes | 10/56 (17.9) | 4:6 | 3/10 (30.0) | 0:3 | 7/46 (15.2) | 4:3 | |||
| CT before tissue analysis: | 0.03 | 0.70 | 0.08 | ||||||
| No | 31/300 (10.3) | 23:8 | 9/30 (30.0) | 8:1 | 22/270 (8.1) | 15:7 | |||
| Yes | 12/55 (21.8) | 5:7 | 4/10 (40.0) | 1:3 | 8/45 (17.8) | 4.4 | |||
| MGMT status: | 0.30 | 0.99 | 0.90 | ||||||
| Unmethylated | 12/139 (8.6) | 5:7 | 0/2 (0.0) | 0:0 | 12/137 (8.8) | 5:7 | |||
| Methylated | 21/161 (13.0) | 15:6 | 7/20 (35.0) | 5.2 | 14/141 (9.9) | 10:4 | |||
| IDH status: | 0.0005 | 0.99 | 0.09 | ||||||
| Wild type | 23/267 (8.6) | 13:10 | 3/9 (33.3) | 2.1 | 20/258 (7.8) | 11:9 | |||
| Mutated | 13/48 (27.1) | 8:5 | 8/23 (34.8) | 5:3 | 5/25 (20.0) | 3:2 | |||
| PD-L1 expression: | 0.15 | NA | 0.77 | ||||||
| 0% | 18/99 (18.2) | 12:6 | 9/19 (47.7) | 7:2 | 9/80 (11.3) | 5:4 | |||
| >0% | 4/51 (7.8) | 3.1 | 0/0 | 2:2 | 4/51 (7.8) | 3:1 | |||