Table 3.

Multivariable analysis of progression-free survival and overall survival.

	Progression-Free Survival		Overall Survival
	Hazard Ratio (95% CI)	p-Value	Hazard Ratio (95% CI)	p-Value
Immunohistochemical loss of MMR protein expression:		0.89		0.50
No	Reference		Reference
Yes	1.05 (0.55 to 2.01)		0.72 (0.28 to 1.86)
Age, years	1.00 (0.98 to 1.02)	0.71	1.01 (0.98 to 1.03)	0.58
Grade:		0.22		0.09
III	Reference		Reference
IV	2.09 (0.64 to 6.79)		4.95 (0.76 to 32.22)
Surgery:		0.10		0.48
Radical	Reference		Reference
Non-radical	1.66 (0.90 to 3.05)		1.34 (0.59 to 3.05)
PS:
0	Reference		Reference
1	1.38 (0.82 to 2.31)	0.22	1.83 (0.85 to 3.92)	0.12
2–3	1.61 (0.85 to 3.05)	0.15	4.87 (1.86 to 12.79)	0.001
MGMT status:		0.14		0.04
Unmethylated	1.41 (0.90 to 2.23)		2.03 (1.01 to 4.08)
Methylated	Reference		Reference
IDH status:		0.007		0.23
Wild type	4.73 (1.54 to 14.48)		2.99 (0.51 to 17.51)
Mutated	Reference		Reference