Table 1.
List of genes involved in key canonical pathways predicted by the Ingenuity Pathway Analysis (IPA) software.
| Canonical Pathways 1 | Genes Up-Regulated | Genes Down-Regulated |
|---|---|---|
| M-PhIP vs. M-CON 2 | ||
| Oxidative Phosphorylation | Atp5g1, Atp5po, Cox17, Cox6b1, Cox7a1, Cyb5a, Atp6, Ndufa2, Ndufa3, Ndufa5, Ndufa8, Ndufa11, Ndufb7, Ndufs6, Ndufs7, Ndufv3 | - |
| Mitochondrial Dysfunction | Atp5g1, Atp5po, Cox17, Cox6b1, Cox7a1, Cyb5a, Fis1, Glrx2, Atp6, Ndufa2, Ndufa3, Ndufa5, Ndufa8, Ndufa11, Ndufb7, Ndufs6, Ndufs7, Ndufv3 | - |
| eIF2 Signaling | Eif3k, Map2k2, Rpl18, Rpl24, Rpl28, Rpl35, Rpl38, Rpl27a, Rpl37a, Rplp2, Rps11, Rps19, Rps20, Rps26 | Ago4, Eif2ak3, Pik3cb, Vegfa |
| Sirtuin Signaling Pathway | Atp5g1, Bax, Map1lc3a, Atp6, Ndufa2, Ndufa3, Ndufa5, Ndufa8, Ndufa11, Ndufb7, Ndufs6, Ndufs7, Ndufv3, Pam16, Sod1, Timm13, Tomm6 | Acss2, Ppargc1a |
| F-PhIP vs. F-CON | ||
| Triacylglycerol Degradation | Abhd6, Ddhd2, Lipe, Lpl | Aadac, Prdx6 |
| Retinol Biosynthesis | Ces1g, Ddhd2, Lipe, Lpl | Aadac |
| Adipogenesis Pathway | Cebpa, Fabp4, Fgfrl1, Lpl, Sap30 | Bmp2, Hif1a, Noct |
1 Short-listed differentially expressed genes were subjected to IPA Core Analysis to predict significant canonical pathways influenced by PhIP treatment; 2 M-PhIP, male mice treated with PhIP; M-CON, control male mice; F-PhIP, female mice treated with PhIP; F-CON, control female mice.