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. 2020 Aug 26;10(9):164. doi: 10.3390/life10090164

Figure 3.

Figure 3

The relationship between cristae modulators and mtDNA organisation. (a) Schematic overview of a normal mitochondrion. (b) Enlarged cristae region depicting the spatial arrangement of key proteins that are necessary for dictating cristae structure and shape, as well as the organisation of the respiratory chain complexes. Proteins that are potentially responsible for the tethering of mtDNA to the IBM are also highlighted. (c) Loss of the fission factor DRP1 has been associated with the formation of mito-bulb structures. These are regions of dense cristae structure which harbour a number of clustered mtDNA molecules. (d) The loss of IMM fusion and cristae shaping protein OPA1 results in mitochondria that display enlarged cristae junctions and a perturbed cristae structure. In addition, mtDNA copy number is reduced. (e) The loss of MICOS components (MIC60, MIC10 and MIC19) has been associated with a complete loss of cristae junctions and the formation of cristae in concentric circles. Nucleoid clustering is evident following the loss of MICOS components.