Table 1.
Significantly over-represented neurological functions among DAGs from three phenotypic subgroups of ASD and a combined case group.
| Nervous System Development and Function Severely Language Impaired (n = 22) | p-Value * | Number of Genes |
|---|---|---|
| Abnormal morphology of neurons | 2.21 × 10−4 | 19 |
| Sensorimotor integration | 3.39 × 10−3 | 2 |
| Neuritogenesis | 3.52 × 10−3 | 19 |
| Maturation of synapse | 4.25 × 10−3 | 3 |
| Size of neurites | 6.09 × 10−3 | 2 |
| Branching of neurites | 6.31 × 10−3 | 11 |
| Maturation of dendritic spines | 7.15 × 10−3 | 2 |
| Development of neurons | 9.24 × 10−3 | 22 |
| Intermediate (n = 121) | ||
| Activation of neuroglia | 7.35 × 10−5 | 11 |
| Activation of astrocytes | 4.77 × 10−4 | 6 |
| Abnormal morphology of neurons | 1.22 × 10−3 | 21 |
| Abnormal morphology of axons | 1.27 × 10−3 | 7 |
| Abnormal morphology of neurites | 1.48 × 10−3 | 9 |
| Loss of neurites | 2.91 × 10−3 | 4 |
| Mild (n = 149) | ||
| Abnormal morphology of nervous system | 4.34 × 10−15 | 297 |
| Sensory system development | 7.77 × 10−15 | 194 |
| Combined (n = 292) | ||
| Abnormal morphology of nervous system | 4.37 × 10−11 | 194 |
| Sensory system development | 6.17 × 10−9 | 121 |
| Abnormal morphology of neurons | 2.26 × 10−8 | 121 |
| Activation of neuroglia | 4.27 × 10−8 | 45 |
* Fisher exact p-value representing the probability that the indicated function is not over-represented among the DAGs for each group, using all genes in IPA’s Knowledgebase as the reference gene set.