Table 2.
Significantly over-represented neurological and developmental disorders among DAGs from the three phenotypic subgroups of ASD and the combined case group.
| Neurological Diseases | p-Value * | Number of Genes |
| Severely language impaired | ||
| Cognitive impairment | 1.32 × 10−5 | 26 |
| Syndromic X⁻linked mental retardation | 2.99 × 10−4 | 6 |
| Mental retardation | 4.13 × 10−3 | 14 |
| Motor dysfunction or movement disorder | 7.75 × 10−3 | 29 |
| Autosomal dominant mental retardation type 11 | 9.94 × 10−3 | 1 |
| Intermediate | ||
| Schizophrenia | 7.73 × 10−4 | 20 |
| Demyelination of nerves | 4.59 × 10−3 | 4 |
| Mild | ||
| Schizophrenia | 1.18 × 10−16 | 184 |
| Motor dysfunction or movement disorder | 5.98 × 10−14 | 393 |
| Movement Disorders | 3.93 × 10−13 | 384 |
| Combined | ||
| Schizophrenia | 1.81 × 10−7 | 106 |
| Developmental Disorders (Severely Language Impaired Only) | p-Value * | Number of Genes |
| Autism or intellectual disability | 3.31 × 10−3 | 15 |
| Autism spectrum disorder or intellectual disability | 3.67 × 10−3 | 17 |
| Dystrophy of muscle | 5.51 × 10−3 | 10 |
* Fisher exact p-value representing the probability that the indicated disorder is not over-represented among the DAGs for each group, using all genes in IPA’s Knowledgebase as the reference gene set.