Impact of age and sex on incision activity. Shown is BER incision activity (individual single measurement scores per animal and group mean ± SEM) of murine liver of adult (24 weeks, n = 10) and old (109-114 weeks, n = 9) animals of both sexes (female: n = 10, male: n = 9) towards (A,D) the 8-oxodG, (B,E) the AP site analogue, and (C,F) the 5-OHdU containing oligonucleotide. Additionally, one representative polyacrylamide gel is shown for (G) the 8-oxodG, (H) the AP site analogue, and (I) the 5-OHdU containing oligonucleotide (full-length gels shown in Figure S3). The left lane shows the respective oligonucleotide blank followed by single sample measurements per lane and a negative control (as described above, marked as (-)) in the right lane. t-test, ** p ≤ 0.01.